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Синдром серповидноклітинної анемії з гемоглобіном D

ORPHA:251370· ICD-10 D57.2· Sickle cell S-D Punjab disease

Визначення(English summary)

A rare, genetic hemoglobinopathy characterized by all the characteristics of sickle cell anemia (SCA). Clinical course is similar to SCA, including acute episodes of pain, splenic infarction and splenic sequestration crisis, vaso-occlusive crisis, acute chest syndrome, ischemic brain injury, osteomyelitis and avascular bone necrosis. The genotype is characterized by an HbS allele in combination with the HbD variant, beta121Glu>Gln.

Поширеність
Unknown
Успадкування
Autosomal recessive
Вік початку
All ages