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SIM1-related Prader-Willi-like syndrome

ORPHA:398079· ICD-10 Q87.1

Definition

A rare Prader-Willi-like syndrome characterized by severe obesity due to SIM1 mutation, in addition to some clinical features of Prader-Willi- syndrome including intellectual disability, developmental delay, behaviour problems and facial dysmorphism. Unlike Prader-Willi syndrome, short stature, hypotonia and hypogonadism may not be observed.

Prevalence
<1 / 1 000 000
Inheritance
Autosomal dominant
Age of onset
Antenatal, Infancy, Neonatal