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46,XY difference of sex development due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency

ORPHA:752· ICD-10 E29.1

Definition

A rare difference of sex development characterized by 17-beta hydroxysteroid dehydrogenase 3 deficiency that affects individuals with a 46,XY karyotype leading to underandrogenization of the genitalia.

Prevalence
1-9 / 1 000 000
Inheritance
Autosomal recessive
Age of onset
Adolescent, Neonatal