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Nijmegen breakage syndrome

ORPHA:647· ICD-10 Q87.8

Definition

A rare, genetic chromosomal instability syndrome presenting at birth with microcephaly, dysmorphic facial features which become more noticeable with age, growth delay, recurring sinopulmonary infections and extremely high frequency of malignancies.

Prevalence
Unknown
Inheritance
Autosomal recessive
Age of onset
Antenatal, Infancy, Neonatal