Kallmann syndrome
ORPHA:478· ICD-10 E23.0
Definition
Kallmann syndrome (KS) is a developmental genetic disorder characterized by the association of congenital hypogonadotropic hypogonadism (CHH) due to gonadotropin-releasing hormone (GnRH) deficiency, and anosmia or hyposmia (with hypoplasia or aplasia of the olfactory bulbs).
- Prevalence
- 1-9 / 100 000
- Inheritance
- Autosomal dominant, Autosomal recessive, Multigenic/multifactorial, X-linked recessive
- Age of onset
- Adolescent, Childhood