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Glycogen storage disease due to hepatic glycogen synthase deficiency

ORPHA:2089· ICD-10 E74.0

Definition

A rare genetically inherited anomaly of glycogen metabolism, considered a form of glycogen storage disease (GSD, or glycogenosis), characterized by post-meal hyperglycemia and fasting hypoglycemia. This is not a glycogenosis, strictly speaking, as there is no storage of glycogen, the enzyme deficiency preventing hepatic glycogen synthesis.

Prevalence
<1 / 1 000 000
Inheritance
Autosomal recessive
Age of onset
Childhood