Paroxysmal cold hemoglobinuria
ORPHA:90035· ICD-10 D59.6
Definition
Paroxysmal cold hemoglobinuria (PCH) is a very rare subtype of autoimmune hemolytic anemia (AIHA), caused by the presence of cold-reacting autoantibodies in the blood and characterized by the sudden presence of hemoglobinuria, typically after exposure to cold temperatures.
- Prevalence
- 1-9 / 1 000 000
- Inheritance
- Multigenic/multifactorial
- Age of onset
- Childhood