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Rhizomelic chondrodysplasia punctata

ORPHA:177· ICD-10 Q77.3

Definition

A rare, primary bone dysplasia characterized by rhizomelic limb shortening, punctate calcifications in cartilage with epiphyseal and metaphyseal abnormalities (chondrodysplasia punctata) and coronal cleft vertebrae associated with profound postnatal growth deficiency, early-onset cataracts, severe intellectual disability and seizures.

Prevalence
Unknown
Inheritance
Autosomal recessive
Age of onset
Antenatal, Neonatal