Familial hyperaldosteronism

Definition

A group of rare primary aldosteronism characterized by hyperaldosteronism, hypertension, hypokalemia and low plasma renin activity. Clinical symptoms and their severity vary according to the type of hyperaldosteronism and may include abnormal production of 18-oxocortisol and 18-hydroxycortisol, headaches, nausea, fatigue, muscle weakness, cardiovascular complications due to aldosterone excess, polydipsia, polyuria, bilateral adrenal hyperplasia, developmental delay, learning disabilities and behavioral abnormalities.