Pituitary gigantism
ORPHA:99725· ICD-10 E22.0
Definition
A rare endocrine disease characterized by excessively tall stature and rapid growth velocity due to growth hormone excess from a pituitary adenoma/hyperplasia occurring before closure of the epiphyseal growth plates. Additional features may include pubertal delay, visual defects, headache, excessive appetite, hyperhidrosis, menstrual irregularity, prognathism, coarse facial features and large hands/feet.
- Prevalence
- Unknown
- Inheritance
- Autosomal dominant, X-linked dominant
- Age of onset
- Adolescent, Childhood, Infancy