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Scleromyxedema without monoclonal gammopathy

ORPHA:90400· ICD-10 L98.5

Definition

Scleromyxedema without monoclonal gammopathy is a form of atypical lichen myxedematosus, characterized by a generalized sclerodermoid infiltration of skin studded with multiple, firm papules of 1-3 mm in diameter involving face (leonine appearance), trunk, and limbs, without monoclonal gammopathy. The involvement of the face can be missing and pruritus may be prominent.

Prevalence
<1 / 1 000 000
Age of onset
Adolescent, Adult, Elderly