Antisynthetase syndrome
ORPHA:81· ICD-10 M35.8
Definition
A rare idiopathic inflammatory myopathy (IIM) characterized principally by myositis, generally symmetrical arthritis and interstitial lung disease (ILD) in association with serum autoantibodies to aminoacyl-transfer RNA synthetases (anti-ARS). More variable features include arthralgia, Raynaud phenomenon, heliotrophic rash, distal esophageal dysmotility and mechanic's hands.
- Prevalence
- 1-9 / 100 000
- Inheritance
- Not applicable
- Age of onset
- Adult, Elderly