C3 glomerulopathy
ORPHA:329918· ICD-10 N03.5
Definition
A form of primary membranoproliferative glomerulonephritis characterized by the presence in renal biopsy samples of a glomerulonephritis with sole (or at least dominant) glomerular immunofluorescence staining for C3. Non-specific alterations or proliferative patterns with C3-dominant glomerular staining are also possible. Based upon electron microscopic findings, C3 glomerulopathy (C3G) may be further classified as C3 glomerulonephritis (C3GN) or Dense deposit disease (DDD).
- Prevalence
- 1-9 / 1 000 000
- Inheritance
- Multigenic/multifactorial
- Age of onset
- All ages