Familial multiple lipomatosis

Definition

A rare genetic subcutaneous tissue disease characterized by slow growth of numerous, painless, encapsulated lipomas located predominantly in the subcutaneous adipose tissue of the trunk and limbs, with relative sparing of the head, neck and shoulders. Clinical presentation mostly becomes evident in the third decade where a significant increase in size and number of lipomas is observed. At this stage they may cause discomfort and difficulty in performing daily physical tasks, otherwise they remain painless.